Gene name:
NR5A2 (B1F;CPF;FTF) ;
Protein name:
Nuclear receptor subfamily 5 group A member 2 ;
Alternative:
B1-binding factor (hB1F) ;Alpha-1-fetoprotein transcription factor ;Hepatocytic transcription factor ;CYP7A promoter-binding factor ;Liver receptor homolog 1 (LRH-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2.
Function:
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSSNSDTGDL | QESLKHGLTP | IGAGLPDRHG | SPIPARGRLV | MLPKVETEAL |
100:
GLARSHGEQG | QMPENMQVSQ | FKMVNYSYDE | DLEELCPVCG | DKVSGYHYGL |
150:
LTCESCKGFF | KRTVQNNKRY | TCIENQNCQI | DKTQRKRCPY | CRFQKCLSVG |
200:
MKLEAVRADR | MRGGRNKFGP | MYKRDRALKQ | QKKALIRANG | LKLEAMSQVI |
250:
QAMPSDLTIS | SAIQNIHSAS | KGLPLNHAAL | PPTDYDRSPF | VTSPISMTMP |
300:
PHGSLQGYQT | YGHFPSRAIK | SEYPDPYTSS | PESIMGYSYM | DSYQTSSPAS |
350:
IPHLILELLK | CEPDEPQVQA | KIMAYLQQEQ | ANRSKHEKLS | TFGLMCKMAD |
400:
QTLFSIVEWA | RSSIFFRELK | VDDQMKLLQN | CWSELLILDH | IYRQVVHGKE |
450:
GSIFLVTGQQ | VDYSIIASQA | GATLNNLMSH | AQELVAKLRS | LQFDQREFVC |
500:
LKFLVLFSLD | VKNLENFQLV | EGVQEQVNAA | LLDYTMCNYP | QQTEKFGQLL |
541:
LRLPEIRAIS | MQAEEYLYYK | HLNGDVPYNN | LLIEMLHAKR | A
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
Protein for Human Nuclear receptor subfamily 5 group A member 2
Protein for Human Nuclear receptor subfamily 5 group A member 2
Protein for Human Nuclear receptor subfamily 5 group A member 2
Protein for Human Nuclear receptor subfamily 5 group A member 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue :
Trachea .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 41-541
10.
"Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1."
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Cell120:343-355(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 300-541 IN COMPLEX WITH NCOA2 AND PHOSPHOLIPIDS
11.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 79-187 IN COMPLEX WITH DNA;MUTAGENESIS OF TYR-96; PHE-168; 169-GLY-PRO-170 AND TYR-172
12.
"Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP."
Ortlund E.A.
,
Lee Y.
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Solomon I.H.
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Hager J.M.
,
Safi R.
,
Choi Y.
,
Guan Z.
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Tripathy A.
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Raetz C.R.H.
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McDonnell D.P.
,
Moore D.D.
,
Redinbo M.R.
Nat. Struct. Mol. Biol.12:357-363(2005)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 290-541 IN COMPLEX WITH NR0B2 AND PHOSPHOLIPID;MUTAGENESIS OF PHE-342 AND ILE-416
13.
"The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1."
Wang W.
,
Zhang C.
,
Marimuthu A.
,
Krupka H.I.
,
Tabrizizad M.
,
Shelloe R.
,
Mehra U.
,
Eng K.
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Nguyen H.
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Settachatgul C.
,
Powell B.
,
Milburn M.V.
,
West B.L.
Proc. Natl. Acad. Sci. U.S.A.102:7505-7510(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 297-541 IN COMPLEX WITH NCOA2 AND PHOSPHOLIPID